Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p62 /SQSTM1 coding plasmid prevents age related macular degeneration in a rat model

28 Aug 2018

Abstract excerpt

P62/SQSTM1, a multi-domain protein that regulates inflammation, apoptosis, and autophagy, has been linked to age-related pathologies. For example, previously we demonstrated that administration of p62/SQSTM1-encoding plasmid reduced chronic inflammation and alleviated osteoporosis and metabolic syndrome in animal models. Herein, we built upon these findings to investigate effect of the p62-encoding plasmid on an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Ocular Diseases and Behçet’s Syndrome
Share to Retinal Diseases and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30153656
DOI: 10.18632/aging.101537

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p62 /SQSTM1 coding plasmid prevents age related macular degeneration in a rat modelPMID 30153656Read ↗

Rat retinal transcriptome: Effects of aging and AMD-like retinopathySemantic proximity Read ↗

Involvement of the autophagic pathway in the progression of AMD-like retinopathy in senescence-accelerated OXYS ratsSemantic proximity Read ↗

Mitochondrial dysfunction in age-related macular degeneration: melatonin as a potential treatmentSemantic proximity Read ↗

Not All Stressors Are Equal: Mechanism of Stressors on RPE Cell DegenerationSemantic proximity Read ↗

PGC-1α Protects RPE Cells of the Aging Retina against Oxidative Stress-Induced Degeneration through the Regulation of Senescence and Mitochondrial Quality Control. The Significance for AMD PathogenesisSemantic proximity Read ↗

Oxidative Stress in Age-Related Macular Degeneration: Nrf2 as Therapeutic TargetSemantic proximity Read ↗

Polarized RPE Secretome Preserves Photoreceptors in Retinal Dystrophic RCS RatsSemantic proximity Read ↗

Senescence-accelerated OXYS rats: A genetic model of premature aging and age-related diseasesSemantic proximity Read ↗

Beacon of Hope for Age-Related Retinopathy: Antioxidative Mechanisms and Pre-Clinical Trials of Quercetin TherapySemantic proximity Read ↗

Exploration of age-related mitochondrial dysfunction and the anti-aging effects of resveratrol in zebrafish retinaSemantic proximity Read ↗

Disruptions of Autophagy in the Rat Retina with Age During the Development of Age-Related-Macular-Degeneration-like RetinopathySemantic proximity Read ↗

Photosensitization of A2E triggers telomere dysfunction and accelerates retinal pigment epithelium senescenceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.