Article
Integrated CRISPR-Cas12a-Based Biosensors with Subwavelength Grating Microring Resonators for Ultrasensitive Mutation-Specific Detection.
ACS sensors - 24 Jul 2026
Zhang Zi-Meng, Xu Chang, Zhu Yao, Wei Yaoming, Pei Yue, Zhang Han, Pang Jianhua, Xie Zhong-Jian, Xu Ke, Wang Jiawei
Abstract excerpt
The rapid and precise detection of nucleic acids is critical for identifying viral mutations, yet it presents formidable difficulties for conventional diagnostics. While established techniques such as quantitative polymerase chain reaction and next-generation sequencing involve complex workflows,...
Topics
- Biosensing Techniques
- CRISPR-Cas Systems
- Mutation
- Gold
- SARS-CoV-2
- Metal Nanoparticles
- Humans
- CRISPR-Associated Proteins
- DNA Probes
- Endodeoxyribonucleases
- Bacterial Proteins