MicroRNAs in the Drosophila bithorax complex.

doi:10.1101/gad.1614208

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Article

MicroRNAs in the Drosophila bithorax complex.

Genes & development - 1 Jan 2008

Bender Welcome

Abstract excerpt

The iab-4 noncoding RNA from the Drosophila bithorax complex is the substrate for a microRNA (miRNA). Gene conversion was used to delete the hairpin precursor of this miRNA; flies homozygous for this deletion are sterile. Surprisingly, this mutation complements with rearrangement breakpoint mutations that disrupt the iab-4 RNA but fails to complement with breaks mapping in the iab-5 through iab-7 regulatory...

Topics

Animals
Base Sequence
Drosophila
Drosophila Proteins
Gene Conversion
Gene Expression Regulation, Developmental
Genes, Insect
Genetic Complementation Test
Homeodomain Proteins
MicroRNAs
Models, Genetic
Molecular Sequence Data
Phenotype
Thorax
Transcription Factors

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Identifiers

PMID: 18172161
DOI: 10.1101/gad.1614208
PMCID: PMC2151010

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