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DNA Methylation Changes in Lung Immune Cells Are Associated with Granulomatous Lung Disease

24 Aug 2018

Abstract excerpt

Epigenetic marks are likely to explain variability of response to antigen in granulomatous lung disease. The objective of this study was to identify DNA methylation and gene expression changes associated with chronic beryllium disease (CBD) and sarcoidosis in lung cells obtained by BAL. BAL cells from CBD (n = 8), beryllium-sensitized (n = 8), sarcoidosis (n = 8), and additional progressive sarcoidosis (n = 9)...

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PMID: 30141971
DOI: 10.1165/rcmb.2018-0177oc

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