Article

A-type lamins anchor emerin at the inner nuclear membrane via two independent binding sites

2025-09-02

Abstract excerpt

Lamins form a dense meshwork at the inner surface of the inner nuclear membrane (INM), where they interact with other nuclear envelope proteins such as emerin. Emerin is an integral membrane protein that is part of the LEM (LAP2/emerin/MAN1) domain family, and mutations in either emerin or lamin A/C can result in Emery-Dreifuss muscular dystrophy (EDMD) and other striated muscle diseases. Emerin is retained at the...

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Literature Corpus work: 13e96e24-2e11-561a-8eac-1d8b09c4aafe
DOI: 10.1101/2025.09.01.673543

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