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Mutations induced by 8-oxo-7,8-dihydroguanine in WRN- and DNA polymerase λ-double knockdown cells.

Mutagenesis - 11 Oct 2018

Kamiya Hiroyuki, Makino Tetsuaki, Suzuki Tetsuya, Kobayashi Miwako, Matsuoka Ichiro

Abstract excerpt

Reactive oxygen species generate 8-oxo-7,8-dihydroguanine (GO, 8-hydroxyguanine), which induces G:C→T:A transversion mutations. The knockdowns of the protein responsible for Werner syndrome (WRN), a cancer-associated DNA helicase, and DNA polymerase (pol) λ, a WRN-interacting DNA pol, cause untargeted base-substitution mutations (action-at-a-distance mutations). To examine the consequences of the dual reductions...

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Identifiers

PMID: 30137433
DOI: 10.1093/mutage/gey024

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WRN

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