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Article

Whole exome sequencing of breast cancer (TNBC) cases from India: association of MSH6 and BRIP1 variants with TNBC risk and oxidative DNA damage.

Molecular biology reports - 1 Oct 2018

Aravind Kumar M, Naushad Shaik Mohammad, Narasimgu Narasimhulu, Nagaraju Naik S, Kadali Srilatha, Shanker Uday, Lakshmi Narasu M

Abstract excerpt

Whole exome sequencing in triple negative breast cancer cases (n = 8) and targeted sequencing in healthy controls (n = 48) revealed BRIP1 rs552752779 (MAF: 75% vs. 6.25%, OR 45.00, 95% CI 9.43-243.32), ERBB2 rs527779103 (MAF: 62.5% vs. 7.29%, OR 21.19, 95% CI 5.11-94.32), ERCC2 rs121913016 (MAF: 56.25% vs. 7.29%, OR 16.34, 95% CI 4.02-70.41), MSH6 rs2020912 (MAF: 56.25% vs. 1.04%, OR 122.13, 95% CI 12.29-2985.48)...

Read the complete abstract on PubMed

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Topics

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Share to BRCA1 Protein
Share to Exome Sequencing
Share to Fanconi Anemia Complementation Group Proteins
Share to Oxidative Stress
Share to Receptor, ErbB-2
Share to RNA Helicases
Share to Triple Negative Breast Neoplasms
Share to Xeroderma Pigmentosum Group D Protein

Source

Identifiers

PMID: 30136158
DOI: 10.1007/s11033-018-4307-4

Genes

MAF
BRIP1
MSH6
ERBB2
ABCC4
AURKA
BRCA1
ERCC2
MMP9
NCOR1
PIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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