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Article

Lineage space and the propensity of bacterial cells to undergo growth transitions.

PLoS computational biology - 1 Aug 2018

Bandyopadhyay Arnab, Wang Huijing, Ray J Christian J

Abstract excerpt

The molecular makeup of the offspring of a dividing cell gradually becomes phenotypically decorrelated from the parent cell by noise and regulatory mechanisms that amplify phenotypic heterogeneity. Such regulatory mechanisms form networks that contain thresholds between phenotypes. Populations of cells can be poised near the threshold so that a subset of the population probabilistically undergoes the phenotypic...

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PMID: 30133447
DOI: 10.1371/journal.pcbi.1006380
PMCID: PMC6122811

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