Article
Non-genetic diversity shapes infectious capacity and host resistance.
Trends in microbiology - 1 Oct 2012
Stewart Mary K, Cookson Brad T
Abstract excerpt
The spontaneous generation of distinct phenotypes within a clonal population of cells allows for both bet-hedging at the population level and the division of labor among subpopulations. This is emerging as an important theme in bacterial pathogenesis, because bacterial pathogens exhibit phenotypic heterogeneity with respect to characteristics that impact virulence. The phenomenon of persister cells and models of...
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