Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells

21 Aug 2018

Abstract excerpt

Sorafenib is the unique accepted molecular targeted drug for the treatment of patients in advanced stage of hepatocellular carcinoma. The current study evaluated cell signaling regulation of endoplasmic reticulum (ER) stress, c‐Jun‐N‐terminal kinase (JNK), Akt, and 5′AMP‐activated protein kinase (AMPK) leading to autophagy and apoptosis induced by sorafenib. Sorafenib induced early (3–12 hr) ER stress...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Cancer Mechanisms and Therapy
Share to Endoplasmic Reticulum Stress and Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30132846
DOI: 10.1002/jcp.26855

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cellsPMID 30132846Read ↗

The role of cell signaling in the crosstalk between autophagy and apoptosis in the regulation of tumor cell survival in response to sorafenib and neratinibSemantic proximity Read ↗

Molecular mechanisms of sorafenib action in liver cancer cellsSemantic proximity Read ↗

miR-183-5p attenuates the effect of sorafenib on human hepatocellular carcinoma via inhibiting SOCS6/JAK2/STAT3 pathwaySemantic proximity Read ↗

Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation.Semantic proximity Read ↗

miR-541 potentiates the response of human hepatocellular carcinoma to sorafenib treatment by inhibiting autophagy.Semantic proximity Read ↗

BAX inhibitor‐1 regulates autophagy by controlling the IRE1α branch of the unfolded protein responseSemantic proximity Read ↗

PFKFB3/HIF-1α feedback loop modulates sorafenib resistance in hepatocellular carcinoma cellsSemantic proximity Read ↗

Hypercholesterolemia-induced impairment in sorafenib functionality is overcome by avasimibe co-treatmentSemantic proximity Read ↗

Mitophagy Promotes Sorafenib Resistance through Hypoxia-Inducible ATAD3A Dependent AxisSemantic proximity Read ↗

Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway.Semantic proximity Read ↗

Selection of autophagy or apoptosis in cells exposed to ER-stress depends on ATF4 expression pattern with or without CHOP expressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.