Article

Hypercholesterolemia-induced impairment in sorafenib functionality is overcome by avasimibe co-treatment

2024-03-28

Abstract excerpt

Avasimibe; a cholesterol-lowering drug with a proven safety in clinical trials, has recently been repositioned as an anticancer agent in various preclinical investigations. A study from our group reported that hypercholesterolemia promotes hepatocellular carcinoma (HCC) cell survival and hampers the anticancer effect of sorafenib, a kinase inhibitor. In the present study, we demonstrate that in HCC under hyperchol...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ee358793-b7f6-5e4b-b3b5-eadef7afa276
DOI: 10.1101/2024.03.27.586757

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hypercholesterolemia-induced impairment in sorafenib functionality is overcome by avasimibe co-treatmentDOI 10.1101/2024.03.27.586757Read

Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation.Semantic proximity Read

Artesunate Sensitizes human hepatocellular carcinoma to sorafenib via exacerbating AFAP1L2-SRC-FUNDC1 axis-dependent mitophagySemantic proximity Read

The Ras/MAPK pathway and hepatocarcinoma: pathogenesis and therapeutic implications.Semantic proximity Read

Evaluation of the effect of biochanin b and Sorafenib on cell survival, growth, migration, colony formation and apoptosis in hepatocellular carcinomaSemantic proximity Read

Targeting WEE1 by adavosertib inhibits the malignant phenotypes of hepatocellular carcinoma.Semantic proximity Read

Cannabigerol potentiates rivoceranib in hepatocellular carcinoma through a receptor-independent ER stress–calcium program that collapses the E2F1–FOXM1 axisSemantic proximity Read

Novel Combination of Sorafenib and Celecoxib Provides Synergistic Anti-Proliferative and Pro-Apoptotic Effects in Human Liver Cancer CellsSemantic proximity Read

Aaptamine Counteracts Statin-Induced PCSK9 Elevation to Improve LDL Receptor Expression and Cholesterol UptakeSemantic proximity Read

Superior efficacy and tolerance of reduced doses of vemurafenib plus anakinra in Erdheim-Chester disease: Towards the paradigm of combined targeting and immune therapies.Semantic proximity Read

The Cytoprotective Role of Autophagy in Response to BRAF-Targeted Therapies.Semantic proximity Read

Computational-experimental repurposing reveals synergistic sorafenib/hydroxychloroquine response in KRAS-mutant breast cancer.Semantic proximity Read

CASK Silence Enhances Chemosensitivity of Hepatocellular Carcinoma Through activating Apoptosis, Inducing JNK/c-Jun-Mediated Autophagic Cell Death and Decreasing ABCG2Semantic proximity Read