Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

miR-541 potentiates the response of human hepatocellular carcinoma to sorafenib treatment by inhibiting autophagy.

Gut - 1 Jul 2020

Xu Wen-Ping, Liu Jin-Pei, Feng Ji-Feng, Zhu Chang-Peng, Yang Yuan, Zhou Wei-Ping, Ding Jin, Huang Chen-Kai, Cui Ya-Lu, Ding Chen-Hong, Zhang Xin, Lu Bin, Xie Wei-Fen

Abstract excerpt

OBJECTIVE: Autophagy participates in the progression of hepatocellular carcinoma (HCC) and the resistance of HCC cells to sorafenib. We investigated the feasibility of sensitising HCC cells to sorafenib by modulating miR-541-initiated microRNA-autophagy axis. DESIGN: Gain- and loss-of-function assays were performed to evaluate the effects of miR-541 on the malignant properties and autophagy of human HCC cells....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Survival

Share to Drug Resistance, Neoplasm

Share to Feasibility Studies

Share to Liver Neoplasms

Share to Neoplasm Recurrence, Local

Share to Sorafenib

Source

Identifiers

PMID: 31727683
DOI: 10.1136/gutjnl-2019-318830

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

miR-541 potentiates the response of human hepatocellular carcinoma to sorafenib treatment by inhibiting autophagy.PMID 31727683Read ↗

MicroRNAs Modulate Drug Resistance-Related Mechanisms in Hepatocellular CarcinomaSemantic proximity Read ↗

MicroRNA-140-5p Suppresses The PD-L1 Level In Exosomes Derived From Hepatocellular Carcinoma Cells, Thereby Attenuating The Chemoresistance, Autophagy And Stemness Induced By Sorafenib In Hepatocellular CarcinomaSemantic proximity Read ↗

Inhibition of the Caveolin-1 pathway promotes apoptosis and overcomes pan-tyrosine kinase inhibitor resistance in hepatocellular carcinomaSemantic proximity Read ↗

The epigenetically regulated miR-494 associates with stem-cell phenotype and induces sorafenib resistance in hepatocellular carcinoma.Semantic proximity Read ↗

CASK Silence Enhances Chemosensitivity of Hepatocellular Carcinoma Through activating Apoptosis, Inducing JNK/c-Jun-Mediated Autophagic Cell Death and Decreasing ABCG2Semantic proximity Read ↗

Sorafenib Resistance in Hepatocellular Carcinoma: The Relevance of Genetic HeterogeneitySemantic proximity Read ↗

TAK1 Is a Novel Target in Hepatocellular Carcinoma and Contributes to Sorafenib Resistance.Semantic proximity Read ↗

HTR1D regulates the PI3K/Akt signaling pathway to impact hepatocellular carcinoma development and resistance to sorafenibSemantic proximity Read ↗

RAS/RAF/MEK/ERK, PI3K/PTEN/AKT/mTORC1 and TP53 pathways and regulatory miRs as therapeutic targets in hepatocellular carcinomaSemantic proximity Read ↗

PRR34-AS1 sponges miR-498 to facilitate TOMM20 and ITGA6 mediated tumor progression in HCCSemantic proximity Read ↗

miR-183-5p attenuates the effect of sorafenib on human hepatocellular carcinoma via inhibiting SOCS6/JAK2/STAT3 pathwaySemantic proximity Read ↗

Artesunate Sensitizes human hepatocellular carcinoma to sorafenib via exacerbating AFAP1L2-SRC-FUNDC1 axis-dependent mitophagySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.