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Article

PFKFB3/HIF-1α feedback loop modulates sorafenib resistance in hepatocellular carcinoma cells

10 Apr 2019

Abstract excerpt

Hepatocellular carcinoma (HCC) is a prevalent malignancy with increasing incidence and extremely poor prognosis worldwide. The multi-kinase inhibitor sorafenib is widely used as a first-line systematic treatment agent of advanced hepatocellular carcinoma. However, the benefit of sorafenib in clinical treatment is often impeded by drug resistance. Therefore, it is of critical importance to investigate the...

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PMID: 30981500
DOI: 10.1016/j.bbrc.2019.03.109

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