Article

Mitophagy Promotes Sorafenib Resistance through Hypoxia-Inducible ATAD3A Dependent Axis

2020-11-11

Abstract excerpt

<h4>Background: </h4> The identification of novel targets for recovering sorafenib resistance is pivotal for Hepatocellular carcinoma (HCC) patients. Mitophagy is the programmed degradation of mitochondria, and is likely involved in drug resistance of cancer cells. Here, we identified hyperactivated mitophagy is essential for sorafenib resistance, and the mitophagy core regulator gene ATAD3A (ATPase family AAA dom...

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Literature Corpus work: 9dc508ad-8ddb-5703-9a53-713e73cfb4a9
DOI: 10.21203/rs.3.rs-48449/v2

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