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Article

An Autism-Related, Nonsense Foxp1 Mutant Induces Autophagy and Delays Radial Migration of the Cortical Neurons.

Cerebral cortex (New York, N.Y. : 1991) - 5 Jul 2019

Li Xue, Han Xin, Tu Xiaomeng, Zhu Dan, Feng Yue, Jiang Tian, Yang Youping, Qu Jia, Chen Jie-Guang

Abstract excerpt

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that has a strong genetic component. Disruptions of FOXP1, a transcription factor expressed in the developing cerebral cortex, were associated with ASD. FOXP1(R525X) is a de novo heterozygous mutation found in patients with autism and severe mental retardation. To explore the neuronal basis of FOXP1(R525X) in ASD, we created Foxp1(R521X), a...

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Identifiers

PMID: 30124790
DOI: 10.1093/cercor/bhy185

Genes

FOXP1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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