Article
De novo mutations in FOXP1 in cases with intellectual disability, autism, and language impairment.
American journal of human genetics - 12 Nov 2010
Hamdan Fadi F, Daoud Hussein, Rochefort Daniel, Piton Amélie, Gauthier Julie, Langlois Mathieu, Foomani Gila, Dobrzeniecka Sylvia, Krebs Marie-Odile, Joober Ridha, Lafrenière Ronald G, Lacaille Jean-Claude, Mottron Laurent, Drapeau Pierre, Beauchamp Miriam H, Phillips Michael S, Fombonne Eric, Rouleau Guy A, Michaud Jacques L
Abstract excerpt
Heterozygous mutations in FOXP2, which encodes a forkhead transcription factor, have been shown to cause developmental verbal dyspraxia and language impairment. FOXP2 and its closest homolog, FOXP1, are coexpressed in brain regions that are important for language and cooperatively regulate developmental processes, raising the possibility that FOXP1 may also be involved in developmental conditions that are...
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