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Article

Intrinsic stability and functional properties of disulfide bond-stabilized coagulation factor VIIIa variants.

Journal of thrombosis and haemostasis : JTH - 1 Jun 2006

Gale A J, Radtke K-P, Cunningham M A, Chamberlain D, Pellequer J-L, Griffin J H

Abstract excerpt

BACKGROUND: The utility of purified coagulation factor (F)VIII for treatment of hemophilia A is limited in part by its instability following activation by thrombin, which is caused by spontaneous dissociation of the A2 domain from the activated FVIII (FVIIIa) heterotrimer. To prevent this A2 doma...

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Source

Identifiers

PMID: 16706977
DOI: 10.1111/j.1538-7836.2006.01951.x

Genes

APC
VWF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16706977-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Intrinsic stability and functional properties of disulfide bond-stabilized coagulation factor VIIIa variants.PMID 16706977Read ↗

Disulfide bond-stabilized factor VIII has prolonged factor VIIIa activity and improved potency in whole blood clotting assays.Semantic proximity Read ↗

Stabilizing interactions between D666-S1787 and T657-Y1792 at the A2-A3 interface support factor VIIIa stability in the blood clotting pathway.Semantic proximity Read ↗

Detailed mechanisms of the inactivation of factor VIIIa by activated protein C in the presence of its cofactors, protein S and factor V.Semantic proximity Read ↗

Increasing hydrophobicity or disulfide bridging at the factor VIII A1 and C2 domain interface enhances procofactor stability.Semantic proximity Read ↗

Cofactor activity in factor VIIIa of the blood clotting pathway is stabilized by an interdomain bond between His281 and Ser524 formed in factor VIII.Semantic proximity Read ↗

Modification of interdomain interfaces within the A3C1C2 subunit of factor VIII affects its stability and activity.Semantic proximity Read ↗

An allosteric disulfide bond is involved in enhanced activation of factor XI by protein disulfide isomerase.Semantic proximity Read ↗

Identification of residues contributing to A2 domain-dependent structural stability in factor VIII and factor VIIIa.Semantic proximity Read ↗

Combining mutations that modulate inter-subunit interactions and proteolytic inactivation enhance the stability of factor VIIIa.Semantic proximity Read ↗

Improved hemostasis in hemophilia mice by means of an engineered factor Va mutant.Semantic proximity Read ↗

Enhanced factor VIIIa stability of A2 domain interface variants results from an increased apparent affinity for the A2 subunit. Results from an increased apparent affinity for the A2 subunit.Semantic proximity Read ↗

The combination of Asp519Val/Glu665Val and Lys1813Ala mutations in FVIII markedly increases coagulation potential.Semantic proximity Read ↗

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