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Article

Somatic HNF1A mutations in the malignant transformation of hepatocellular adenomas: a retrospective analysis of data from MSK-IMPACT and TCGA.

Human pathology - 1 Jan 2019

Hechtman Jaclyn F, Abou-Alfa Ghassan K, Stadler Zsofia K, Mandelker Diana L, Roehrl Michael H A, Zehir Ahmet, Vakiani Efsevia, Middha Sumit, Klimstra David S, Shia Jinru

Abstract excerpt

Mutations of Hepatocyte-Nuclear-Factor-1-Homeobox-A (HNF1A) gene and loss of Liver-Fatty-Acid-Binding-Protein (LFABP) are well documented in hepatocellular adenoma. However, the role of HNF1A mutations in hepatocellular carcinoma remains to be determined. In this study, all hepatocellular neoplasms evaluated by our institutional Memorial Sloan Kettering-Integrated Mutational Profiling of Actionable Clinical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30121369
DOI: 10.1016/j.humpath.2018.08.004
PMCID: PMC6365190

Genes

CTNNB1
IMPACT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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