Article
The phenomena of balanced effect between α-globin gene and of β-globin gene.
BMC medical genetics - 17 Aug 2018
Zhong Liangying, Gan Xin, Xu Lingling, Liang Chujia, Xie Yingjun, Lin Wenbin, Chen Peisong, Liu Min
Abstract excerpt
BACKGROUND: Thalassemias (TM) are the most common autosomal recessive disorders in Southeast Asian countries. Both α- and β-thalassemia lead to a decrease or absence of globin chains. The most serious of the thalassemia syndromes is thalassemia major which is characterized by a transfusion dependent anemia and subsequent iron overload caused by repeated blood transfusions. It is preventive by genotyping the...
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