The polymorphism rs35767 at IGF1 locus is associated with serum urate levels.

doi:10.1038/s41598-018-29665-3

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Article

The polymorphism rs35767 at IGF1 locus is associated with serum urate levels.

Scientific reports - 16 Aug 2018

Mannino Gaia C, Fuoco Anastasia, Marini Maria A, Spiga Rosangela, Di Fatta Concetta, Mancuso Elettra, Perticone Francesco, Andreozzi Francesco, Sesti Giorgio

Abstract excerpt

Previous studies suggested that the IGF-1/IGF-1 receptor signaling pathway may contribute to regulate uric acid levels. To confirm this hypothesis, we assessed the effects of the IGF-1-raising genetic variant rs35767 on urate levels in serum and urine, and we investigated IGF-1 ability to modulate the expression of transporters involved in reabsorption and secretion of uric acid in the kidney. The study...

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PMID: 30115944
DOI: 10.1038/s41598-018-29665-3
PMCID: PMC6095867

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IGF1

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