Association between polymorphism at IGF-1 rs35767 gene locus and long-term decline in renal function: a Japanese retrospective longitudinal cohort study.

doi:10.1186/s12882-021-02408-9

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Article

Association between polymorphism at IGF-1 rs35767 gene locus and long-term decline in renal function: a Japanese retrospective longitudinal cohort study.

BMC nephrology - 2 Jun 2021

Honda Kosuke, Kuriyama Satoru, Ichida Kimiyoshi, Nakano Tomoko, Sugano Naoki, Yokoo Takashi

Abstract excerpt

BACKGROUND: Insulin-like growth factor-1 (IGF-1) acts on glucose and protein metabolism and human growth and also influences blood pressure and renal function. This study investigated whether the single-nucleotide polymorphism of IGF-1, rs35767, plays a role in metabolic syndrome indicators, including blood pressure, glucose metabolism, uric acid levels, and renal function. METHODS: In this retrospective...

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PMID: 34078313
DOI: 10.1186/s12882-021-02408-9
PMCID: PMC8173978

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