Article
Genetic susceptibility to neuroblastoma.
Current opinion in genetics & development - 1 Feb 2017
Tolbert Vanessa P, Coggins Grace E, Maris John M
Abstract excerpt
Until recently, the genetic basis of neuroblastoma, a heterogeneous neoplasm arising from the developing sympathetic nervous system, remained undefined. The discovery of gain-of-function mutations in the ALK receptor tyrosine kinase gene as the major cause of familial neuroblastoma led to the discovery of identical somatic mutations and rapid advancement of ALK as a tractable therapeutic target. Inactivating...
Topics
- Alleles
- Anaplastic Lymphoma Kinase
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Homeodomain Proteins
- Humans
- Mutation
- Neuroblastoma
- Polymorphism, Single Nucleotide
- Receptor Protein-Tyrosine Kinases
- Transcription Factors