Article
Monocytes are involved in the balance between regulatory T cells and Th17 cells in severe drug eruptions.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Nov 2018
Ushigome Yukiko, Mizukawa Yoshiko, Kimishima Momoko, Yamazaki Yoshimi, Takahashi Ryo, Kano Yoko, Shiohara Tetsuo
Abstract excerpt
BACKGROUND: Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DiHS/DRESS) is a distinct phenotype of severe drug eruptions characterized by sequential reactivations of herpesviruses. Although a progressive loss of suppressive function in regulatory T cells (Tregs) occurred during the course of DiHS/DRESS, but not in Stevens-Johnson syndrome/toxic epidermal necrolysis...
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