Article
The Progress of Gene Therapy for Leber's Optic Hereditary Neuropathy.
Current gene therapy - 1 Jan 2017
Zhang Yong, Tian Zhen, Yuan Jiajia, Liu Chang, Liu Hong Li, Ma Si Qi, Li Bin
Abstract excerpt
INTRODUCTION: Leber's Optic Hereditary Neuropathy (LHON) is a common cause of teenaged blindness in both eyes for which there is currently no effective treatment. In 1871, the German ophthalmologist Theodor Leber was the first to describe the clinical characteristics of his namesake disease, and through unremitting efforts over the past 100 years, researchers have continued to increase their understanding of...
Topics
- DNA, Mitochondrial
- Genetic Predisposition to Disease
- Genetic Therapy
- Humans
- Mutation
- NADH Dehydrogenase
- Optic Atrophy, Hereditary, Leber
- Translational Research, Biomedical