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Article

Noninvasive Detection of ctDNA Reveals Intratumor Heterogeneity and Is Associated with Tumor Burden in Gastrointestinal Stromal Tumor.

Molecular cancer therapeutics - 1 Nov 2018

Namløs Heidi M, Boye Kjetil, Mishkin Skyler J, Barøy Tale, Lorenz Susanne, Bjerkehagen Bodil, Stratford Eva W, Munthe Else, Kudlow Brian A, Myklebost Ola, Meza-Zepeda Leonardo A

Abstract excerpt

Molecular analysis of circulating tumor DNA (ctDNA) has a large potential for clinical application by capturing tumor-specific aberrations through noninvasive sampling. In gastrointestinal stromal tumor (GIST), analysis of KIT and PDGFRA mutations is important for therapeutic decisions, but the invasiveness of traditional biopsies limits the possibilities for repeated sampling. Using targeted next-generation...

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Identifiers

PMID: 30097488
DOI: 10.1158/1535-7163.MCT-18-0174

Genes

KIT
PDGFRA

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