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Article

Clinical Use of Liquid-Based Comprehensive Genomic Profiling in Gastrointestinal Stromal Tumors.

Laboratory investigation; a journal of technical methods and pathology - 1 May 2025

Mechahougui Hiba, Hildebrand Lindsey, Haberberger James, Sivakumar Smruthy, Saiji Essia, Tukachinsky Hanna, Madison Russell, Killian Jonathan K, Huang Richard S P, Elvin Julia A, Marks Eric, Heinrich Michael C, Koessler Thibaud, Lin Douglas I

Abstract excerpt

Treatment for gastrointestinal stromal tumor (GIST) focuses on tyrosine kinase inhibitors, the selection of which depends on specific mutations. We sought to determine the clinical use of liquid biopsy in advanced GIST. Liquid (n = 181) (FoundationOne Liquid CDx) and tissue (n = 2198) (FoundationOne and FoundationOne CDx) comprehensive genomic profiling of GIST were evaluated. The presence of circulating tumor...

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Share to Circulating Tumor DNA
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gastrointestinal Stromal Tumors

Share to Imatinib Mesylate

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Share to Receptor, Platelet-Derived Growth Factor alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 39984125
DOI: 10.1016/j.labinv.2025.104116
PMCID: PMC12147398

Genes

TF
KIT
BRAF
EGFR
FGFR2
NF1
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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