Functional and Biochemical Characterization of Three Recombinant Human Glucose-6-Phosphate Dehydrogenase Mutants: Zacatecas, Vanua-Lava and Viangchan.

doi:10.3390/ijms17050787

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Functional and Biochemical Characterization of Three Recombinant Human Glucose-6-Phosphate Dehydrogenase Mutants: Zacatecas, Vanua-Lava and Viangchan.

International journal of molecular sciences - 21 May 2016

Gómez-Manzo Saúl, Marcial-Quino Jaime, Vanoye-Carlo America, Serrano-Posada Hugo, González-Valdez Abigail, Martínez-Rosas Víctor, Hernández-Ochoa Beatriz, Sierra-Palacios Edgar, Castillo-Rodríguez Rosa Angélica, Cuevas-Cruz Miguel, Rodríguez-Bustamante Eduardo, Arreguin-Espinosa Roberto

Abstract excerpt

Glucose-6-phosphate dehydrogenase (G6PD) deficiency in humans causes severe disease, varying from mostly asymptomatic individuals to patients showing neonatal jaundice, acute hemolysis episodes or chronic nonspherocytic hemolytic anemia. In order to understand the effect of the mutations in G6PD gene function and its relation with G6PD deficiency severity, we report the construction, cloning and expression as...

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PMID: 27213370
DOI: 10.3390/ijms17050787
PMCID: PMC4881603

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