Antagonistic pleiotropy for carbon use is rare in new mutations.

Abstract excerpt

Pleiotropic effects of mutations underlie diverse biological phenomena such as ageing and specialization. In particular, antagonistic pleiotropy ("AP": when a mutation has opposite fitness effects in different environments) generates tradeoffs, which may constrain adaptation. Models of adaptation typically assume that AP is common - especially among large-effect mutations - and that pleiotropic effect sizes are...

Topics

• Adaptation, Physiological
• Carbon
• Escherichia coli
• Genetic Pleiotropy
• Mutation
• Selection, Genetic