Article
Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment.
Nature communications - 9 Aug 2018
Quevedo Camilo E, Cruz-Migoni Abimael, Bery Nicolas, Miller Ami, Tanaka Tomoyuki, Petch Donna, Bataille Carole J R, Lee Lydia Y W, Fallon Phillip S, Tulmin Hanna, Ehebauer Matthias T, Fernandez-Fuentes Narcis, Russell Angela J, Carr Stephen B, Phillips Simon E V, Rabbitts Terence H
Abstract excerpt
Targeting specific protein-protein interactions (PPIs) is an attractive concept for drug development, but hard to implement since intracellular antibodies do not penetrate cells and most small-molecule drugs are considered unsuitable for PPI inhibition. A potential solution to these problems is to select intracellular antibody fragments to block PPIs, use these antibody fragments for target validation in disease...
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