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Article

Pharmacological induction of heat shock proteins ameliorates toxicity of mutant PKCγ in spinocerebellar ataxia type 14.

The Journal of biological chemistry - 21 Sept 2018

Nakazono Aoi, Adachi Naoko, Takahashi Hideyuki, Seki Takahiro, Hamada Daizo, Ueyama Takehiko, Sakai Norio, Saito Naoaki

Abstract excerpt

Amyloid and amyloid-like protein aggregations are hallmarks of multiple, varied neurodegenerative disorders, including Alzheimer's and Parkinson's diseases. We previously reported that spinocerebellar ataxia type 14 (SCA14), a dominant-inherited neurodegenerative disease that affects cerebellar Purkinje cells, is characterized by the intracellular formation of neurotoxic amyloid-like aggregates of genetic...

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Identifiers

PMID: 30093405
DOI: 10.1074/jbc.RA118.002913
PMCID: PMC6153279

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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