Article
Challenges in ALK inhibition of ALK-positive non-small-cell lung cancer: from ALK positivity detection to treatment strategies after relapse.
Future oncology (London, England) - 1 Sept 2018
Cortinovis Diego, Canova Stefania, Abbate Maria I, Colonese Francesca, Cogliati Viola, Bidoli Paolo
Abstract excerpt
ALK positivity, despite representing only in a small proportion of patients with non-small-cell lung cancer, is worth researching at diagnosis given the possibility to treat these patients with some targeted ALK inhibitors, which are more potent than chemotherapy. Thanks to understanding the resistance mechanisms, newer and more selective inhibitors are now available in clinical practice. Hence, this disease...
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