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Article

Detecting Resistance to Therapeutic ALK Inhibitors in Tumor Tissue and Liquid Biopsy Markers: An Update to a Clinical Routine Practice.

Cells - 15 Jan 2021

Hofman Paul

Abstract excerpt

The survival of most patients with advanced stage non-small cell lung cancer is prolonged by several months when they are treated with first- and next-generation inhibitors targeting ALK rearrangements, but resistance inevitably emerges. Some of the mechanisms of resistance are sensitive to novel ALK inhibitors but after an initial tumor response, more or less long-term resistance sets in. Therefore, to adapt...

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Share to Anaplastic Lymphoma Kinase
Share to Drug Resistance, Neoplasm
Share to Epithelial-Mesenchymal Transition

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement

Share to Liquid Biopsy

Share to Neoplastic Cells, Circulating

Share to Protein Kinase Inhibitors

Share to Receptor Protein-Tyrosine Kinases

Source

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Identifiers

PMID: 33467720
DOI: 10.3390/cells10010168
PMCID: PMC7830674

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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