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Article

Low-Level Brain Somatic Mutations Are Implicated in Schizophrenia.

Biological psychiatry - 1 Jul 2021

Kim Myeong-Heui, Kim Il Bin, Lee Junehawk, Cha Do Hyeon, Park Sang Min, Kim Ja Hye, Kim Ryunhee, Park Jun Sung, An Yohan, Kim Kyungdeok, Kim Seyeon, Webster Maree J, Kim Sanghyeon, Lee Jeong Ho

Abstract excerpt

BACKGROUND: Somatic mutations arising from the brain have recently emerged as significant contributors to neurodevelopmental disorders, including childhood intractable epilepsy and cortical malformations. However, whether brain somatic mutations are implicated in schizophrenia (SCZ) is not well established. METHODS: We performed deep whole exome sequencing (average read depth > 550×) of matched dorsolateral...

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PMID: 33867114
DOI: 10.1016/j.biopsych.2021.01.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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