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Downregulation of FOXO3a by DNMT1 promotes breast cancer stem cell properties and tumorigenesis

11 Jul 2019

Abstract excerpt

Breast cancer stem cells (BCSCs) are tumor initiating cells that can self-renew and are highly tumorigenic and chemoresistant. Therefore, the identification of factors critical for BCSC function is vital for the development of therapies. Here, we report that DNMT1-mediated FOXO3a promoter hypermethylation leads to downregulation of FOXO3a expression in breast cancer. FOXO3a is functionally related to the...

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PMID: 31296961
DOI: 10.1038/s41418-019-0389-3

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