Article
First detection of TR46/Y121F/T289A and TR34/L98H alterations in Aspergillus fumigatus isolates from azole-naive patients in Denmark despite negative findings in the environment.
Antimicrobial agents and chemotherapy - 1 Sept 2014
Astvad K M T, Jensen R H, Hassan T M, Mathiasen E G, Thomsen G M, Pedersen U G, Christensen M, Hilberg O, Arendrup M C
Abstract excerpt
Azole-resistant Aspergillus fumigatus harboring the TR34/L98H or TR46/Y121F/T289A alterations is increasingly found in Europe and Asia. Here, we present the first clinical cases of TR46/Y121/T289A and three cases of TR34/L98H outside the cystic fibrosis (CF) population in Denmark and the results of environmental surveys. Four patients (2012 to 2014) with 11 A. fumigatus and 4 Rhizomucor pusillus isolates and 239...
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