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Amino acid mutations in the capsid protein produce novel porcine circovirus type 2 neutralizing epitopes.

Veterinary microbiology - 30 Aug 2013

Liu Jianbo, Huang Liping, Wei Yanwu, Tang Qinghai, Liu Dan, Wang Yiping, Li Shengbin, Guo Longjun, Wu Hongli, Liu Changming

Abstract excerpt

Porcine circovirus type 2 (PCV2) is associated with postweaning multisystemic wasting syndrome in pigs. A monoclonal antibody (mAb) 8E4 against the PCV2 capsid protein has the capacity to neutralize the virus. However, this mAb can only react with some PCV2a strains (LG, CL, and JF2; mAb 8E4-positive strains), but does not cross-react with some PCV2b strains (YJ and JF; mAb 8E4-negative strains). In the present...

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Identifiers

PMID: 23582511
DOI: 10.1016/j.vetmic.2013.03.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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