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A Nanostructured Lipid Carrier for Delivery of a Replicating Viral RNA Provides Single, Low-Dose Protection against Zika

2 Aug 2018

Abstract excerpt

Since the first demonstration of in vivo gene expression from an injected RNA molecule almost two decades ago, 1 the field of RNA-based therapeutics is now taking significant strides, with many cancer and infectious disease targets entering clinical trials. 2 Critical to this success has been advances in the knowledge and application of delivery formulations. Currently, various lipid nanoparticle (LNP) platforms...

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PMID: 30078765
DOI: 10.1016/j.ymthe.2018.07.010

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