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Article

Acetaminophen-NAPQI hepatotoxicity: a cell line model system genome-wide association study.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Mar 2011

Moyer Ann M, Fridley Brooke L, Jenkins Gregory D, Batzler Anthony J, Pelleymounter Linda L, Kalari Krishna R, Ji Yuan, Chai Yubo, Nordgren Kendra K S, Weinshilboum Richard M

Abstract excerpt

Acetaminophen is the leading cause of acute hepatic failure in many developed nations. Acetaminophen hepatotoxicity is mediated by the reactive metabolite N-acetyl-p-benzoquinonimine (NAPQI). We performed a "discovery" genome-wide association study using a cell line-based model system to study the possible contribution of genomics to NAPQI-induced cytotoxicity. A total of 176 lymphoblastoid cell lines from...

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Identifiers

PMID: 21177773
DOI: 10.1093/toxsci/kfq375
PMCID: PMC3044203

Genes

HSF1
HSF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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