The Lysosomal Protein Arylsulfatase B Is a Key Enzyme Involved in Skeletal Turnover.

doi:10.1002/jbmr.3563

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Article

The Lysosomal Protein Arylsulfatase B Is a Key Enzyme Involved in Skeletal Turnover.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Dec 2018

Pohl Sandra, Angermann Alexandra, Jeschke Anke, Hendrickx Gretl, Yorgan Timur A, Makrypidi-Fraune Georgia, Steigert Anita, Kuehn Sonja C, Rolvien Tim, Schweizer Michaela, Koehne Till, Neven Mona, Winter Olga, Velho Renata Voltolini, Albers Joachim, Streichert Thomas, Pestka Jan M, Baldauf Christina, Breyer Sandra, Stuecker Ralf, Muschol Nicole, Cox Timothy M, Saftig Paul, Paganini Chiara, Rossi Antonio, Amling Michael, Braulke Thomas, Schinke Thorsten

Abstract excerpt

Skeletal pathologies are frequently observed in lysosomal storage disorders, yet the relevance of specific lysosomal enzymes in bone remodeling cell types is poorly defined. Two lysosomal enzymes, ie, cathepsin K (Ctsk) and Acp5 (also known as tartrate-resistant acid phosphatase), have long been known as molecular marker proteins of differentiated osteoclasts. However, whereas the cysteine protease Ctsk is...

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PMID: 30075049
DOI: 10.1002/jbmr.3563

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