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Article

Overlapping functions of lysosomal acid phosphatase (LAP) and tartrate-resistant acid phosphatase (Acp5) revealed by doubly deficient mice.

Development (Cambridge, England) - 1 Dec 2001

Suter A, Everts V, Boyde A, Jones S J, Lüllmann-Rauch R, Hartmann D, Hayman A R, Cox T M, Evans M J, Meister T, von Figura K, Saftig P

Abstract excerpt

To date, two lysosomal acid phosphatases are known to be expressed in cells of the monocyte/phagocyte lineage: the ubiquitously expressed lysosomal acid phosphatase (LAP) and the tartrate-resistant acid phosphatase-type 5 (Acp5). Deficiency of either acid phosphatase results in relatively mild phenotypes, suggesting that these enzymes may be capable of mutual complementation. This prompted us to generate LAP/Acp5...

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PMID: 11731469
DOI: 10.1242/dev.128.23.4899

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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