Article
Cathepsins in the Pathophysiology of Mucopolysaccharidoses: New Perspectives for Therapy.
Cells - 15 Apr 2020
De Pasquale Valeria, Moles Anna, Pavone Luigi Michele
Abstract excerpt
Cathepsins (CTSs) are ubiquitously expressed proteases normally found in the endolysosomal compartment where they mediate protein degradation and turnover. However, CTSs are also found in the cytoplasm, nucleus, and extracellular matrix where they actively participate in cell signaling, protein processing, and trafficking through the plasma and nuclear membranes and between intracellular organelles. Dysregulation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.