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Article

Induced Mutation Proves a Potential Target for TB Therapy: A Molecular Dynamics Study on LprG.

Cell biochemistry and biophysics - 1 Sept 2018

Machaba Kgothatso E, Mhlongo Ndumiso N, Soliman Mahmoud E S

Abstract excerpt

Molecular dynamics (MD) simulations of wild-type and V91W mutant Mycobacterium tuberculosis-LprG (Mtb-LprG) were performed with the goal to provide a comprehensive understanding of the Mtb-LprG as a potential antimycobacterial target. A long-range MD simulations and post-MD analyzes led us to various results that plainly explained the impact of V91W mutation on Mtb-LprG. Herein, the results revealed that the...

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PMID: 30073572
DOI: 10.1007/s12013-018-0852-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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