Article
Growth arrested live-attenuated Leishmania infantum KHARON1 null mutants display cytokinesis defect and protective immunity in mice.
Scientific reports - 2 Aug 2018
Santi Ana Maria Murta, Lanza Juliane Sousa, Tunes Luiza Guimarães, Fiuza Jacqueline Araújo, Roy Gaétan, Orfanó Alessandra da Silva, de Carvalho Andréa Teixeira, Frézard Frédéric, Barros André Luís Branco de, Murta Silvane Maria Fonseca, do Monte-Neto Rubens Lima
Abstract excerpt
There is no safe and efficacious vaccine against human leishmaniasis available and live attenuated vaccines have been used as a prophylactic alternative against the disease. In order to obtain an attenuated Leishmania parasite for vaccine purposes, we generated L. infantum KHARON1 (KH1) null mutants (ΔLikh1). This gene was previously associated with growth defects in L. mexicana. ΔLikh1 was obtained and confirmed...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.