DDX3 DEAD-box RNA helicase (Hel67) gene disruption impairs infectivity of Leishmania donovani and induces protective immunity against visceral leishmaniasis

Abstract excerpt

Abstract Visceral leishmaniasis (VL) is a vector-borne disease caused by the digenetic protozoan parasiteLeishmania donovanicomplex. So far there is no effective vaccine available against VL. The DDX3 DEAD-box RNA Helicase (Hel67) is 67 kDa protein which is quite essential for RNA metabolism, amastigote differentiation, and infectivity inL. major and L. infantum. To investigate the role ofHel67in theL. donovani,...

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