Article
A positive feedback loop bi-stably activates fibroblasts
26 Jul 2018
Abstract excerpt
Although fibroblasts are dormant in normal tissue, they exhibit explosive activation during wound healing and perpetual activation in pathologic fibrosis and cancer stroma. The key regulatory network controlling these fibroblast dynamics is still unknown. Here, we report that Twist1, a key regulator of cancer-associated fibroblasts, directly upregulates Prrx1, which, in turn, increases the expression of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.