Article
Analysis of KIR3DP1 Polymorphism Provides Relevant Information on Centromeric KIR Gene Content.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2018
Bono Maria, Pende Daniela, Bertaina Alice, Moretta Alessandro, Della Chiesa Mariella, Sivori Simona, Zecca Marco, Locatelli Franco, Moretta Lorenzo, Bottino Cristina, Falco Michela
Abstract excerpt
Four killer cell Ig-like receptor (KIR) genes, collectively referred to as framework genes, characterize almost all KIR haplotypes. In particular, KIR3DL3 and KIR3DL2 mark the ends of the locus, whereas KIR3DP1 and KIR2DL4 are located in the central part. A recombination hot spot, mapped between KIR3DP1 and KIR2DL4, splits the haplotypes into two regions: a centromeric (Cen) region (spanning from KIR3DL3 to...
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