Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional profiling of HERV-K(HML-2) in amyotrophic lateral sclerosis and potential implications for expression of HML-2 proteins

2 Aug 2018

Abstract excerpt

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder. About 90% of ALS cases are without a known genetic cause. The human endogenous retrovirus multi-copy HERV-K(HML-2) group was recently reported to potentially contribute to neurodegeneration and disease pathogenesis in ALS because of transcriptional upregulation and toxic effects of HML-2 Envelope (Env) protein. Env and other...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to Chromosomal and Genetic Variations
Share to Neurogenetic and Muscular Disorders Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30068350
DOI: 10.1186/s13024-018-0275-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional profiling of HERV-K(HML-2) in amyotrophic lateral sclerosis and potential implications for expression of HML-2 proteinsPMID 30068350Read ↗

Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosisSemantic proximity Read ↗

Retroviral Elements in Pathophysiology and as Therapeutic Targets for Amyotrophic Lateral SclerosisSemantic proximity Read ↗

Endogenous retroviruses are dysregulated in ALSSemantic proximity Read ↗

Quantitative analysis of human endogenous retrovirus-K transcripts in postmortem premotor cortex fails to confirm elevated expression of HERV-K RNA in amyotrophic lateral sclerosisSemantic proximity Read ↗

Plasma exosomal HERV-K transcripts are increased in amyotrophic lateral sclerosisSemantic proximity Read ↗

Human endogenous retrovirus-K contributes to motor neuron disease.Semantic proximity Read ↗

Analysis of transcribed human endogenous retrovirus W env loci clarifies the origin of multiple sclerosis-associated retrovirus envsequencesSemantic proximity Read ↗

Human endogenous retrovirus HERV-K(HML-2) RNA causes neurodegeneration through Toll-like receptorsSemantic proximity Read ↗

A HML6 endogenous retrovirus on chromosome 3 is upregulated in amyotrophic lateral sclerosis motor cortexSemantic proximity Read ↗

HIV-1 Infection Leads to Increased Transcription of Human Endogenous Retrovirus HERV-K (HML-2) Proviruses<i>In Vivo</i>but Not to Increased Virion ProductionSemantic proximity Read ↗

Human Endogenous Retrovirus-K and TDP-43 Expression Bridges ALS and HIV NeuropathologySemantic proximity Read ↗

Genomic analysis of ERVWE2 locus in patients with multiple sclerosis: absence of genetic association but potential role of human endogenous retrovirus type W elements in molecular mimicry with myelin antigenSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.