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Article

Autophagy mediates epithelial cancer chemoresistance by reducing p62/SQSTM1 accumulation.

PloS one - 1 Jan 2018

Battista R Alessia, Resnati Massimo, Facchi Cecilia, Ruggieri Elena, Cremasco Floriana, Paradiso Francesca, Orfanelli Ugo, Giordano Leone, Bussi Mario, Cenci Simone, Milan Enrico

Abstract excerpt

To cope with intrinsic and environmental stress, cancer cells rely on adaptive pathways more than non-transformed counterparts. Such non-oncogene addiction offers new therapeutic targets and strategies to overcome chemoresistance. In an attempt to study the role of adaptive pathways in acquired drug resistance in carcinoma cells, we devised a model of in vitro conditioning to three standard chemotherapeutic...

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Identifiers

PMID: 30067838
DOI: 10.1371/journal.pone.0201621
PMCID: PMC6070274

Genes

SQSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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