Fragile X founder chromosome effects: linkage disequilibrium or microsatellite heterogeneity?

doi:10.1002/ajmg.1320510421

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Article

Fragile X founder chromosome effects: linkage disequilibrium or microsatellite heterogeneity?

American journal of medical genetics - 15 Jul 1994

Zhong N, Ye L, Dobkin C, Brown W T

Abstract excerpt

Previous studies of founder chromosome effects in fragile X have been based on linkage disequilibrium with either FRAXAC1 or DXS548 alone or combined with FRAXAC2. Recently, we found no linkage disequilibrium of FMR-1 with FRAXAC2, but rather, found FRAXAC2 was complex and highly mutable. Therefo...

Topics

Alleles
Crossing Over, Genetic
DNA Primers
DNA, Satellite
Female
Founder Effect
Fragile X Syndrome
Gene Frequency
Genetic Heterogeneity
Haplotypes
Heterozygote
Humans
Linkage Disequilibrium
Male
Molecular Epidemiology
Molecular Sequence Data
Mutation
New York

Source

Open in PubMed

Identifiers

PMID: 7943008
DOI: 10.1002/ajmg.1320510421

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7943008-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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