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Article

Fragile X founder chromosome effects: linkage disequilibrium or microsatellite heterogeneity?

American journal of medical genetics - 15 Jul 1994

Zhong N, Ye L, Dobkin C, Brown W T

Abstract excerpt

Previous studies of founder chromosome effects in fragile X have been based on linkage disequilibrium with either FRAXAC1 or DXS548 alone or combined with FRAXAC2. Recently, we found no linkage disequilibrium of FMR-1 with FRAXAC2, but rather, found FRAXAC2 was complex and highly mutable. Therefore, we have now analyzed FRAXAC1 and DXS548 together for haplotypes, two markers which have not been jointly analyzed...

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PMID: 7943008
DOI: 10.1002/ajmg.1320510421

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