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Article

Retained Plasticity and Substantial Recovery of Rod-Mediated Visual Acuity at the Visual Cortex in Blind Adult Mice with Retinal Dystrophy.

Molecular therapy : the journal of the American Society of Gene Therapy - 3 Oct 2018

Nishiguchi Koji M, Fujita Kosuke, Tokashiki Naoyuki, Komamura Hiroshi, Takemoto-Kimura Sayaka, Okuno Hiroyuki, Bito Haruhiko, Nakazawa Toru

Abstract excerpt

In patients born blind with retinal dystrophies, understanding the critical periods of cortical plasticity is important for successful visual restoration. In this study, we sought to model childhood blindness and investigate the plasticity of visual pathways. To this end, we generated double-mutant (Pde6ccpfl1/cpfl1Gnat1IRD2/IRD2) mice with absent rod and cone photoreceptor function, and we evaluated their...

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Source

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Identifiers

PMID: 30064895
DOI: 10.1016/j.ymthe.2018.07.012
PMCID: PMC6171050

Genes

GNAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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